Differential regulation of TROP 2 release by PKC
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Incorporation of arachidonic acid and its release from rat Leydig cells
These results, that there is a different temporal profile of release of LH and G H by PDBu, a differential action of two PKC inhibitors on this release and also that an L-type CaZ+channel blocker can completely inhibit PDBu-induced release of GH but not LH, indicate strongly that regulation of hormone secretion by PKC is very differently organized in the cell types involved. It is known that LH...
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Elevated extracellular calcium ([Ca2+]o) and other agonists potentially acting via the calcium-sensing receptor (CaR) increase parathyroid hormone-related peptide (PTHrP) release from H-500 Leydig cells. Here, we provide strong evidence for the CaR's involvement by using a dominant negative CaR that attenuates high [Ca2+]o-induced PTHrP release. This effect is likely transcriptional, because hi...
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تاریخ انتشار 2017